Zdenka Sklubalova | Conference 2019 Skip to main content

Assoc.Prof. Pharm Dr. Zdenka Šklubalová, Ph.D
Charles University, Faculty of Pharmacy in Hradec Králové, Acting head of Department of Pharmaceutical Technology

 

Abstract

 

Fractal aspects of pharmaceutical powders' flow
 

Particulate materials are fundamental for pharmaceutical manufacturing of dosage forms. As powder flowability and packing properties directly affect the processing, precise characterization of the flow and consolidation behaviour is necessary. Apart from the external conditions as well as given testing conditions, flow is influenced by the properties of the individual particles. However, bulk flow is essentially an emerging property so the influence of individual particles can be less pronounced when more representative particle aggregates exist that dominate overall flow.
In line with the objective, a fractal approach by the particle linear fractal dimension and the bulk fractal dimension of the powder bed surface of dynamically moving particle assemblies will be discussed.

 

Biography

 

2011         Assoc. Prof. in Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové
1999         Ph.D. degree in Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové

Membership
•    Associate Editor of European Journal of Hospital Pharmacy - Science and Practice
•    Chair of Board for Postgraduate Study on Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové
•    European Pharmacopoeial Committee, Member of Group 12 (Dosage forms), EDQM, Strasbourg
•    Czech Pharmacopoeial Committee of the Ministry of Health, Head of the Section of Pharmaceutical Technology
•    Czech Pharmacopoeial Committee of the Ministry of Health, Member of group for Stability of extemporaneous preparations, the Section of Pharmacy
•    Czech Pharmaceutical Association, Member of the Section of Pharmaceutical Technology

Teaching activities
Pharmaceutical Technology
Hospital compounding of pharmaceutical preparations
2 EU e-learning projects within last 5 years

Significant achievements
36 original scientific papers
over 30 conference papers
4 patents (CZ, WO, US)

Recent supported projects
2018-2020 Project No. 1286218/2018 of Grant Agency of Charles University. Study of fractal aspects of flow and consolidation behaviour of pharmaceutical excipients as prospective carriers for interactive mixtures with drugs. Mentor of the Ph.D. student (applicant)
2015-2018 Project No. 322315/2015 of Grant Agency of Charles University. The study of fractal aspects of flowability of particulate matter in pharmaceutical technology. Mentor of the Ph.D. student (applicant)
2011-2015 Project TAČR TA01010128. Investigation of lyophilized lablets for allergen vaccines. Technology Agency of the Czech Republic, No. TA01020573, co-applicant
6 industry-related projects within last 5 years

Research activities
Particulate solids in pharmaceutical technology
- fractal aspects of powder flow
- evaluation of static and dynamic flow properties
Formulation aspects of liquid dosage forms
- extemporaneous paediatric preparations
- stability testing
Formulation aspects of sterile dosage forms
- optimization of dose uniformity for eye drops
- viscosity prediction for hydrogels
Dissolution testing
- testing of dosage forms using USP 1 and USP 4 method
- kinetic of drug dissolution